International modular courses in regulatory toxicologic. Letter regarding chronic oral exposure to synthetic amorphous silica nm200 results in renal and liver lesions in mice. See actions taken by the people who manage and post content. Pdf aerosols of synthetic amorphous silica do not induce fibrosis.
Chronic oral exposure to synthetic amorphous silica kidney. Society of toxicologic pathology toxicoloic atoloy of te diestive tact an anceas portland, oregon oregon convention center june 16 20, 20 3. Registration fees members of the medical cluster, chf 550. Sree chitra tirunal institute for medical sciences and technology announces an international modular courses in regulatory toxicologic pathology. Yes, klaus, cofounder of anapath gmbh, took the challenge and recently qualified as the 498th boardcertified diplomate of the japanese society of toxicologic pathology jstp.
Anapath gmbh 2 huntingdon life sciences 3 bayer schering pharma ag 4 harlan laboratories ltd. Overseas participants who applied early registration are required to visit the registration counter. Anapath services is a glpcertified, swiss based contract laboratory specialized in histopathology services. Only little is known about the microbial changes and more importantly their functional impact in the chronic dss colitis model. Relationship of metabolism and cell proliferation to the. Kw anapath gmbh works as a consultant for and nd who is a member of the.
Klaus weber ta lked about ho w test models ma y differ from co n ventiona l animal models and th at test models may incl ude the use of nude mice, immuno competen t mice, hamsters, or othe r animal. Oral repeateddose toxicity studies of bia 102474 in beagle. Morfeld p, bosch a, weber k, heinemann m, krueger n 2017. Klaus weber 1, rainer ernst 2, heinz fankhauser 3, jerry f. Chronic colitis was induced in balbc mice by feeding of 2% dss in drinking water for 7 days followed by. Klaus weber is an artist who strays through multiple disciplines and appears to take on various professional rolesfrom engineer to anthropologist, from beekeeper to anatomistin his ongoing exploration of natural and sociopolitical forces, questioning our social, physical, psychological and ontological relationships with the environments we. With more than 30 years professional experience, he started. The first module will be organised between 08 th and 11 th february, 2017 4 days at thiruvannathapuram to cover the following topics.
The advantages of using rats in toxicity testing were summarized by kacew and festing 1996 as a metabolic pathway similarities to humans, b numerous similar anatomical and physiological characteristics, c a large database, which is extremely important for comparative purposes, and d the ease of breeding and maintenance of animals at relatively low cost. Intestinal uptake of particles european food safety. Inflammatory bowel diseases are multifactorial disorders of the gastrointestinal tract with rising incidence worldwide. Pdf in a subchronic week inhalation toxicity study with a terminal sacrifice after. Journal of the french society of pathology and the french society of clinical cytology.
Heterotopic peripheral nerves related to sternal abnormalities in two male b6c3f1 mice. Histopathology services and toxicologic pathology anapath. Peter morfeld1,2, axel bosch 3, klaus weber4, mario heinemann and nils krueger5 1 institute for occupational epidemiology and risk assessment of evonik industries ag, essen, germany 2 institute and policlinic for occupational medicine, environmental medicine and preventive research, university of cologne, germany. Disease development is accompanied by changes in bacterial. Furthermore, one of the authors kw was the study pathologist on all of the studies.
Hayes, yoshimasa okazaki, and klaus weber were paid consultants of bial. Single day visit on either monday or tuesday, chf 370. One of both males was a control group animal that was sacrificed at the terminal schedule on study day 728. Hardisty 4, wolfram heider 5, and karla stevens 6 1 harlan laboratories ltd. Klaus weber anapath gmbh and anapath services are independent, privately owned swiss based contract laboratories specialized in. The anapath gmbh is proud to announce and welcome a new boardcertified pathologist in the team. Toxicity and safety in regards to the use of aluminum adjuvants is highly controversial and also confused by conflicting study results. To develop alternative treatments for retinoblastoma, pascualpasto et al. Pdf thyroid dysplasia in wistar hannover galas rats.
Several chemicals have been found to induce lung tumors in the mouse but not in the rat. Anapath services gmbh hammerstrasse 49 liestal, 4410. Klaus weber ceo, pathologist anapath gmbh linkedin. They found that vcn01 can lyse even chemoresistant patient samples in vitro and was effective in mouse. The intestinal uptake of particles and the implications for drug and antigen delivery.
Eyes afflicted by chemoresistant retinoblastoma may need to be surgically removed to prevent lifethreatening metastasis. Released 20110712 received 20110319 accepted 20110321. Peter morfeld1,2, axel bosch 3, klaus weber4, mario heinemann and nils krueger5 1institute for occupational epidemiology and risk assessment of evonik industries ag, essen, germany 2institute and policlinic for occupational medicine, environmental medicine and preventive research, university of cologne, germany 3wacker chemie ag, burghausen. Therapeutic efficacy of a combined sage and bitter apple. Jan 27, 2017 jurgen laufs, klaus weber anapath services gmbh, switzerland correspondence. The authors thank ansgar buettner histovia gmbh, overath, germany and klaus weber anapath gmbh, liestal, switzerland for the histopathological evaluations. The cif of anapath research sa is a08925935 and its current trading status is active. Annelaure leoni, katrin weber, klaus weber eurofins biopharma product testing munich gmbh, planegg, germany 4 vascular imaging by novel contrast agent to advance preclinical models nils warfving anapath services gmbh, liestal, switzerland 5 thermal dissipation in active implantable medical devices for neuroengineering jorge morales.
The society of toxicologic pathology thanks the toxicologic. Analysis of their human relevance using the ipcs framework christian strupp, 1 deborah a. Article views are the countercompliant sum of full text article downloads since november 2008 both pdf and html across all institutions and individuals. Using the acute dextran sulfate sodium dssinduced colitis model, studies have demonstrated that intestinal inflammation is accompanied by major changes in the composition of the intestinal microbiota. The level of their expert knowledge in oncogencity studies, neuropathology, inhalation pathology, sperm and ovary staging, bone marrow evaluation or cardiovascular pathology is rare to find in. Aluminum is currently the most commonly used vaccine adjuvant. Its raison detre has and remains to be a wholly owned medical pathologist practice with emphasis on high quality. Green, 5 stefan kaiser, 4 stephen corney, 4 ailsa jackson, 4 and agustin casadesus 6.
Jun 30, 2011 klaus weber, 1 vasanthi mowat, 2 elke hartmann, 3 tanja razinger, 4 hansjorg chevalier, 1 kai blumbach, 4 owen p. These metrics are regularly updated to reflect usage leading up to the last few days. Wallace hayes, and klaus weber were paid consultants of bial. Differences in types and incidence of neoplasms in wistar. Regulatory toxicologic pathology sree chitra tirunal institute for. Klaus weber anapath gmbh and anapath services are independent, privately owned swiss based contract laboratories specialized in histopathology services. Stem cell research alan trounson, kyle kolaja, thomas petersen.
Current standard therapies are only partially effective and often show severe adverse effects. Differences in types and incidence of neoplasms in wistar han. Programme stakeholder workshop on nanoscience and nanotechnology parma, 12 april 2019 the european food safety authority published in july 2018 its guidance on human and animal health aspects part 1 of the risk assessment of the application of nanoscience and. Klaus weber, anapath gmbh, buchsweg 56, oberbuchsiten, switzerland.
Supplementary data the following are the supplementary data related to this article. Neoplastic and nonneoplastic lesions in the charles river wistar hannover crl. Please bear with us if loading is slow, or try to reload the page. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. These include trichloroethylene green, 2000, naphthalene, ethylbenzene, alphamethylstyrene, cumene, divinylbenzene, benzofuran cruzan et al. We used a refined model of chronic dssinduced colitis that. Certification of our pathologist klaus weber by the japanese society of toxicologic pathology is another indication of our global scientific recognition. A substantial quantity of data on spraguedawley sd and hannover wistar rats strains have been published concerning their source, diet, and housing conditions, as well as the incidences of nonneo. Programme stakeholder workshop on nanoscience and nanotechnology parma, 12 april 2019 the european food safety authority published in july 2018 its guidance on human and animal health aspects part 1 of the risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain.
Intestinal uptake of particles european food safety authority. Currently, anapath diagnostics inc specializes in hematology and pathologist with 2 physicians. Klaus weber anapath gmbh symposium 3 modernization of toxicologic pathology day 2, february 14, friday 14. Pathology in continuous infusion studies in rodents andnon. The metabolic activation and cell proliferative effects by several of these. Klaus weber, anapath gmbh, buchsweg 56, 4625 oberbuchsiten.
Oral repeateddose toxicity studies of bia 102474 in. Relationship of metabolism and cell proliferation to the mode. Company information anapath services gmbh 28040163736 age. Pathology in continuous infusion studies in rodents and. We did not want to reduce further the file size of the images as we do not want to compromise on quality. Therapeutic targeting of the rb1 pathway in retinoblastoma. A substantial quantity of data on spraguedawley sd and hannover wistar rats strains have been published concerning their source, diet, and housing conditions, as well as the incidences of nonneoplastic lesions and neoplasms observed in different laboratories. Aquatic toxicology 146 2014 1276 table 1 summary of experimental designs and reported outcomes from four laboratory studies of diclofenac in trout. Aerosols of synthetic amorphous silica do not induce fibrosis in. Open access ec pharmacology and toxicology case report. Klaus weber was born in east germany and became a veterinarian and a. Letter regarding chronic oral exposure to synthetic.
Elmore, ms, dvm, dabt, fiatp, dacvp, ntp and niehs, research triangle park, nc the object of this interactive symposium is to provide continuing education on interpreting pathology slides, to generate lively and productive conversation, and to have a good time. Pathology in continuous infusion studies in rodents and non. Anapath diagnostics inc is a group practice with 1 location. Facebook is showing information to help you better understand the purpose of a page. Nevertheless, aluminum is a well demonstrated toxin in biological systems and its specific. Particles intestinal uptake pathological indicators for reflux related changes in oral gavage studies synthetic amorphous silica. About anapath research based near barcelona, anapath research s. In general, it is regarded as safe by the pharmaceutical industry and the various regulatory agencies. Inhibitors of this enzyme increase endogenous levels of fatty acid amides, including the endocannabinoid anandamide, and are considered potential therapeutic. First innoqua seminar on nonclinical drug development.
Min gi osaka city university katsuhiro miyajima tokyo university of agriculture s31 application of a humanized liver model in toxicity studies hiroshi suemizu. Nils warfving, anapath services gmbh, hammerstrasse 49, ch4410 liestal, switzerland, tel 0041619064000. Presentations these presentations are compiled on up to 100 slides and many images. Anapath is a team of scientists of different nationalities who are internationally. Klaus weber, anapath gmbh, oberbuchsiten, switzerland, presented pathology techniques to aid the development and understanding of. Analysis of their human relevance using the ipcs framework, toxicological sciences, volume 128, issue 1, july 2012, pages 284294. Differences in types and incidence of neoplasms in wistar han and. Relationship of metabolism and cell proliferation to the mode of action of fluensulfoneinduced mouse lung tumors. Oral repeateddose toxicity studies of bia 102474 in cynomolgus. Anapath gmbh in switzerland, a holding covering nowadays ten. Gordon, martina jaeger, klaus weber, relationship of metabolism and cell proliferation to the mode of action of fluensulfoneinduced mouse lung tumors.
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